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MGF (Mechano Growth Factor) is a variant of IGF-1 (Insulin Like Growth Factor-1), also available as synthetic, water-based variant with less stability. MGF is generally derived from exercised or injured/damaged muscle tissue. The biomolecule mimic IGF gene expression that augments stem cell population in the muscle tissue to promote hyperplasia. Addition of polyethylene glycol (PEG) with the compound prevents spontaneous degradation in the blood stream, and increase plasma half-life. PEG MGF is a variant of IGF, which is produced by the shift of IGF gene, and the PEGylation of the molecule, which is essential for improving its stability. PEGylated Mechano factor is the new form of IGF and the hormone functions by increasing the formation of new muscle cells. When the stem cells are increased the muscle mass increases effectively.

Synthetic MGF travels through bloodstream and is not affected by the condition of the serum although it has a short half-life when in contact with serum. The PEGylation or addition of a polyethene glycol molecule to the structure is essential in increasing the potency , activity and effectiveness of PEG-MGF. The PEG acts a protective coat, which prevents degradation of the polypeptide from the internal enzymes and other chemical factors. Moreover the polyethene glycol molecules offers more binding sites to the molecule which allows for increased affinity to the perfect ligand during interactions. The polypeptide is usually negatively charged and any positively charged compound would affect its integrity and activity therefore reducing its lifespan, however with the enhanced coat the lifespan and activity is enhanced to an optimal level. There are various research and studies conducted on the use of the polypeptide in enhancing muscle hyperplasia.

PEG MGF Chemical Profile

Formula: C121H200N42O39

Molecular weight: 2888.16

Chain: Tyr-Gln-Pro-Pro-Ser-Thr-Asn-Lys-Asn-Thr-Lys-Ser-Gln-Arg-Arg-Lys-Gly-Ser-Thr-Phe-Glu-Glu-Arg-Lys



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